ABSTRACT
Objective: To determine the frequency of common etiologies of erythroderma in patients visiting a tertiary care hospital in Karachi
Methods: In this cross-sectional study, in a period from May, 2015 to November, 2015,190 patients attending the outpatient department or admitted in the dermatology ward of Civil Hospital, Karachi and fulfilling inclusion criteria[15 to 60 years of age, male/female, having erythroderma for 1week or more], were enrolled in this study after taking written informed consent. History taking and physical examination were done to assess etiology. Skin biopsy was sent for histopathology
Results: The age range was from 15 to 60 years [mean age 48.6 + 16.9 years] while mean duration of disease was 17.9 + 9.1 days. Out of 190 patients, 116 [61%] were male and 74 [39%] were female. The most common etiology was eczema 73 [38.4%] followed by psoriasis 51 [26.8%], drugs 45 [23.7%] and lymphoma 21[11.1%]
Conclusion: Eczema was the commonest etiology seen in our study. The different etiologies of erythroderma in our patients were not similar to those reported from other parts of the world
ABSTRACT
Objective: To determine the patterns of psoriasis in pediatric group
Methods: In this cross-sectional study, 30 patients meeting inclusion criteria were included by nonprobability consecutive sampling technique in a period of 6 months. Patients aged 1 month to 14 years, visiting dermatology OPD or getting admitted in Department of Dermatology, CHK, were examined by a dermatologist to make a diagnosis of psoriasis and its particular pattern. Biopsies were taken wherever required. Frequency and percentages were computed for age, gender, pattern of psoriasis, severity of diseases and site of involvement
Results: The median age of patients was 8 years, majority [56.7%] falling in the range of 6-10 years with equal gender distribution. Most of the patients presented with plaque type of psoriasis [43.3%], followed by guttate [13.3%], palmoplantar [10%] and nail involvement [10%]. Psoriatic diaper rash and erythrodermic variety were seen in only 6.7% patients each. Lesions were primarily on the trunk [33.3%]. However, only 1-10% of body surface was involved in 50% of the patients, but at the same time 22.2% patients reported a greated invovlement falling in range of 30-90% body surface area
Conclusion: We conclude that plaque type is the most common pattern of psoriasis seen in children of our region and trunk is the most commonly affected site
ABSTRACT
Objective: To determine the frequency of hepatitis B and hepatitis C in psoriatic patients
Study Design: Prospective cross-sectional study
Place and Duration of Study: This study was conducted at the Dermatology Department of a Tertiary Health Care Facility, Dow University of Health Sciences and Civil Hospital Karachi from January 2014 to December 2014
Materials and Methods: Irrespective of age and sex, a total of 47 patients with diagnosis of psoriasis and psoriatic arthritis were enrolled for this study
Results: Out of 47 eligible subjects, 89.4 % were male. Most of the patients [36 %] had a body involvement of 25- 50 % and the commonest type of psoriasis was plaque type. On further analysis, 8 % of the subjects were found to be positive for HBsAg on ICT method, but only 6.4 % confirmed positive on CMI techniques. Anti HCV Antibody reported positive in 10.6 % of the patients on ICT methods and the same results confirmed on CMI techniques
Conclusion: The number of psoriatic patients suffering from hepatitis B and C virus is not very much significant but should be considered. Once it is positive, then the treatment options are totally different
ABSTRACT
Objective To determine the frequency of psoriatic arthritis [PsA] and its different clinical patterns in patients of Psoriasis
Methods In this cross-sectional descriptive study, conducted at Dermatology Unit, Civil Hospital, Karachi from January, 2015 to August, 2015, 200 patients of 18-60 year age and of either gender, having psoriasis with joint pain for at least 3 months were analyzed
Results Mean age of study population was 47.5+/-13.4 years. Out of 200 patients, 94 [47%] were male and 106 [53%] were female. 79 [39.5%] patients had PsA: oligoarthritis 26 [37%], symmetric 24 [34%], axial joint involvement 18 [25%], classical distal interphalangeal [DIP] 6 [8%] and arthritis mutilans 5[7 %]
Conclusion About one-third of psoriatic patients had PsA. Significant clinical presentations of PsA included oligoarthritis, symmetric, axial joint involvement, classical DIP and arthritis mutilans. Certain clinical features may be highly associated with the development of PsA in psoriatic patients
ABSTRACT
OBJECTIVE: To determine the frequency of new onset diabetes mellitus type II in patients of psoriasis attending tertiary care hospital
METHODS: This cross-sectional study done in the out-patient department, Department of Dermatology, Dow University of Health Sciences and Civil Hospital Karachi. Diagnosed cases of psoriasis meeting the inclusion criteria were selected and relevant history taken. Fasting blood sugar levels were checked two times. Informed consent was taken from all the patients. Categorical variables were expressed in frequency and percentage, whereas numerical variables were expressed in mean and standard deviation. Stratification was done with regards to age, gender and duration of psoriasis 1-5 years, to find out the effect of duration upon onset of Diabetes
The data was analyzed using SPSS version 17
RESULTS: Of 114 patients 63 [55.3%] were less than 50 years of age with mean age of 48.8+/-7.3 years and 77 [67.5%] were male with male to female ratio of 2.1:1. Of 114 patients, 68 [59.6%] had duration of psoriasis less than 2 years with mean duration of 3.5+/-2.3 years. Of 114 patients, 9 [7.9%] had blood sugar >126 mg/dl with mean blood sugar 113+/-24.2 mg/dl. Frequency of new onset type II diabetes was 9 [7.9%]. Stratified analysis showed that new onset type II DM is more common in female patients of < 50 years of age
CONCLUSIONS: It is concluded from this study that patients with psoriasis are at the risk of developing type II diabetes and these patients should be screened for diabetes
ABSTRACT
To determine the frequency of superficial fungal infections in renal transplant recipients. This cross-sectional study was conducted in the outpatient clinic, Department of Dermatology, Dow University of Health Sciences and Civil Hospital Karachi. Patients of 20-60 year of age undergone renal transplant 3 to 12 months back were enrolled while patients with diabetes were excluded from study. Patients were evaluated for the presence of superficial mycoses. Skin scrapings and nail clippings were collected mycologic evaluation. A total of 62 patients were enrolled. The mean age of enrolled patients was 39.9 +/- 10.3 years and 37 [59.7%] were male. The mean duration of transplant was 7.6 +/- 2.9 months. 23 [37.1%] were on steroids. Fungal infections were documented in 38 [61.3%] patients. Of 38 patients, 19 [50%] had candidiasis. Stratified analysis showed fungal infections to be similar in >/=40 or <40 years of age [63.6% v. 58.6%], female and male [64% vs. 59.5%]; duration of transplant <8 or >8 months [63.9% vs. 57.7%] and those who were on steroids [69.6%] or other drugs [62.5%]. It is concluded from this study that patient's undergone renal transplant has increased frequency of fungal infection